I used to sail out of Channel Islands Harbor which has it's entrance right next to Port Hueneme's entrance just on the other side of Silver Strand Beach. I some times sailed right in front of that Port Hueneme harbor entrance and never noticed any patrols. Regardless, I would give those places a wide berth.
When I sailed up from San Diego I averaged staying 3 to 6 miles off shore. Always safer out there. Make sure you take a chart with you. The one I most often refer to is the one is 18740 San Diego To Santa Rosa Island, but that doesn't cover you past Port Hueneme.
http://www.charts.noaa.gov/OnLineViewer/18740.shtml
You also want to try to stay away from the shipping lanes marked in red.
I also recommend buying the Chart Pack that contains the whole coast from San Francisco to Ensanada.
I know that Don Anderson has made the trip a few times and he's a member of EY.org
http://www.andersonsailingcharters.com/
Don's a real nice guy. Check his web site and give him a call. I am sure he could give you some good advice. 60 miles is a long trip. I did about 70 miles from the bottom of San Diego Harbor in Chula Vista to Dana Point and it took me about 17 1/2 hours. I would leave well before dawn or early in the evening because the winds usually come up in the afternoon and they are almost always on your nose when sailing up the coast. You also have a bout a knot and a half current against you.
A great book to check out is Brian Fagen's Crusing Guide.
http://search.barnesandnoble.com/Cr...hern-California/Brian-M-Fagan/e/9780071374644
Wish I had the time to go with you.